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Lifespan: Why We Age--And Why We Don't Have To
David A. Sinclair & Matthew D. LaPlante
The book argues that aging is not an inevitability but a treatable disease, driven by the Information Theory of Aging—a loss of epigenetic information rather than genetic data. Drawing on ancestral survival circuits, the author, a Harvard professor, reveals how sirtuins and other pathways regulate healthspan. He critiques "Whack-a-Mole Medicine" that treats symptoms, not the underlying cause, advocating for a shift in perception and public policy. The text explores lifestyle interventions like calorie restriction and exercise, alongside molecular breakthroughs such as NAD boosters, metformin, rapamycin, senolytics, and cellular reprogramming, which hold the potential to dramatically extend human vitality. Ethical and societal implications of a longer-lived population are also discussed.